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KMID : 0377220030280010050
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Medical Journal of Chosun Univercity
2003 Volume.28 No. 1 p.50 ~ p.58
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Results of Palliative Radiotherapy to the Metastatic Brain Tumor
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Ko Young-Sam
Oh Yoon-Kyeong
Nam Taek-Keun
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Abstract
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Background and Obiectives : To evaluate the role of palliative radiotherapy in the treatment of metastatic brain tumor with respect to response, survival and prognostic factors, retrospectively
Materials ðods : From Jan 1998 to Jan 2003, a total of 57 patients diagnosed as metastatic brain tumor were referred for palliative radiotherapy Of them, forty-four patients were eligible for this study. The most common primary tumor was lung cancer in 31 patients (70.5%). A total doses of 27.5-40.0 Gy were delivered to whole brain with daily doses of 2.0-3.0 Gy To evaluate the treatment response, all patients were evaluated by neurological functional classification prior to and after radiotherapy
Results : The positive response was noted in 36 patients (81.8%) and 8 patients (18.2%) did not improve. The median survival time of all patients was 6 months. 1-and 2-year survival rates were 17.4% and 2.9%, respectively. The median survival time of patients younger than 60 vs older were 9 vs 4 months (p=0.009), respectively. The median survival time of patients with stable vs progressive vs unknown primary status were 9 vs 4 vs 5 months (p=0.003), respectively Multivariate analysis showed that age and primary tumor status were independently significant prognostic factors affecting survival.
Conclusion : The radiotherapy could relieve neurological symptoms effectively and promptly in most patients and prolong survival of patients. The most significant factors affecting survival were age and primary tumor status, and therefore more definitive treatment modality including surgical resection or radiosurgery should be considered in the patients with favorable prognostic factors.
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KEYWORD
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Metastatic brain tumor, Palliative radiotherapy
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